IRS1 anticorps (AA 1192-1242)

N° du produit ABIN7448979

Cet anticorps anti-IRS1 est un anticorps Lapin Polyclonal détectant IRS1 dans IHC et IF (p). Adapté pour Humain.

Aperçu rapide pour IRS1 anticorps (AA 1192-1242) (ABIN7448979)

Antigène: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRS1 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-IRS1 anticorps

Épitope: AA 1192-1242

Fonction: Rabbit anti-IRS1 IHC Antibody, Affinity Purified

Homologie: Mouse,Rabbit,Pig,Gorilla,Chimpanzee,Naked mole rat

Purification: Affinity Purified

Immunogène: Between AA 1192 and 1242

Isotype: IgG

Information d'application

Indications d'application:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur IRS1

Antigène: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Autre désignation: IRS1

Sujet: Background: The insulin receptor substrate 1 (IRS1) is one of four members of the IRS family (IRS1-4) that mediates intracellular signaling downstream of the IGF1 and insulin receptors. Phosphorylation of IRS1 by activated receptors leads to binding of IRS to the SH2 domains of effector proteins such as PI3K, Grb2, nck, and SHP2. The downstream effects of insulin and IGF1 signaling via IRSs on the cell are pleiotropic and include various responses such as glucose transport, glycogen synthesis, protein synthesis, antilipolysis, and gluconeogenesis. Polymorphisms in IRS1 may contribute to the etiology of non-insulin-dependent diabetes mellitus (NIDDM).

ID gène: 3667

NCBI Accession: NP_005535

UniProt: P35568

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process